洪明奇榮譽主任

:::

基本資料

姓名：洪明奇／Mien-Chie Hung
任職單位：癌症生物學研究所專任講座教授
分子醫學中心榮譽主任
美國德州大學安德森癌症中心基礎研究副校長暨分子細胞腫瘤學系主任
電話：713-7923668
E-mail：mhung@mdanderson.org

學經歷

美國麻省Brandeis大學分子生物學博士 1978-83

美國德州大學安德森癌症中心癌症生物學系/分子細胞腫瘤學系主任 1998-

中央研究院院士 2002-

美國德州大學安德森癌症中心基礎研究副校長 2010-

中國醫藥大學附設醫院分子醫學中心榮譽主任 2006-

中國醫藥大學癌症生物學研究所/生物醫學研究所講座教授2007-

專長

細胞及分子生物學
腫瘤學

獲獎／Award

德州大學休斯頓健康科學中心John P. McGovern傑出教職員獎(1990,1993,1999)
德州大學安德森癌症中心,教育傑出教授獎(1993)、基礎醫學研究傑出教授獎(1998)
中央研究院院士(2002)
德州大學健康科學教育學院院士(2006)
德州大學安德森癌症中心特聘講座教授(2007)
科學諮詢委員會：Susan G. Komen正式會員(2010-2016)
美國科學促進學會生物科學部會士(AAAS Fellow) (2010-)
美國華人生物科學學會總統獎 (2011)
國立台灣大學傑出校友獎 (2014)

Recent Publications

Wu, T-J., Chang, S-S., Li, C-W., Hsu, Y-H., Chen, T-C., Lee, W-C., Yeh, C-T. and Hung, M-C. Severe hepatitis promotes hepatocellular carcinoma recurrence and metastasis via TNF/NF-B/snail pathway-mediated epithelial-mesenchymal transition after curative resection. Clin Cancer Res (in press), 2015. (SCI, IF: 8.722)
Liao, H-W., Hsu, J-M., Xia, W., Wang, H-L., Wang, Y-N., Chang, W-C., Arold, S. T., Chou, C-K., Tsou, P-H., Yamaguchi, H., Fang, Y-F., Lee, H-J,. Lee, H-H., Tai, S-K., Yang, M-H., Morelli, M. P., Sen, M., Ladbury, J. E., Chen, C-H., Grandis, J. R., Kopetz, S. and Hung, M-C. Methylation of EGFR by PRMT1 regulates EGFR signaling and cetuximab response. J Clin Invest (in press), 2015. (SCI, IF: 13.215)
Li, C-W., Xia, W., Lim, S-O., Hsu, J. L., Huo, L., Wu, Y., Li, L-Y., Lai, C-C., Chang, S-S., Hsu, Y-H., Sun, H-L., Kim, J., Yamaguchi, H., Lee, D-F., Wang, H., Wang, Y., Chou, C-K., Hsu, J-H., Lai, Y-J., LaBaff, A. M., Ding, Q., Ko, H-W., Tsai, F-J., Tsai, C-H., Hortobagyi, G. N. and Hung, M-C. AKT1-mediated inhibition of breast cancer epithelial-mesenchymal transition requires phosphorylation-dependent Twist degradation. Cancer Res (in press), 2015. (SCI, IF: 9.329)
Lee, H-J., Lan, L., Peng, G., Chang, W-C., Hsu, M-C., Wang, Y-N., Cheng, C-C., Wei, L., Nakajima, S., Chang, S-S., Liao, H-W., Chen, C-H., Lavin, M., Ang, K. K., Lin, S-Y. and Hung, M-C. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res 25(2):225-236, 2015. (SCI, IF: 12.413)
Lin, C-Y., Chen, H-J., Huang, C-C., Lai, L-C., Lu, T-P., Tseng, G-C., Kuo, T-T., Kuok, Q-Y., Hsu, J. L., Sung, S-Y., Hung, M-C.* and Sher, Y-P.* ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Res 74(18):5229-5243, 2014. (SCI, IF: 9.329) *Co-corresponding authors.
Hsu, Y-H., Yao, J., Chan, L-C., Wu, T-J., Hsu, J. L., Fang, Y-F., Wei, Y., Wu, Y., Huang, W-C., Liu, C-L., Chang, Y-C., Wang, M-Y., Li, C-W., Shen, J., Chen, M-K., Sahin, A. A., Sood, A., Mills, G. B,. Yu, D., Hortobagyi, G. N. and Hung, M-C. Definition of PKC-α, CDK6, and MET as therapeutic targets for triple-negative breast cancer. Cancer Res 74(17):4822-4835, 2014. (SCI, IF: 9.329)
Chou, R-H., Wang, Y-N., Hsieh, Y-H., Li, L-Y., Xia, W., Chang, W-C., Chang, L-C., Cheng, C-C., Lai, C-C., Hsu, J. L., Chang, W-J., Chiang, S-Y., Lee, H-J., Liao, H-W., Chuang, P-H., Chen, H-Y., Kuo, S-C., Chen, C-H., Yu, Y-L.* and Hung, M-C.* EGFR modulates DNA synthesis and repair through Tyr phosphorylation of Histone H4. Dev Cell 30(2):224-237, 2014. (SCI, IF: 9.708) *Co-corresponding authors.
Chiou, G-Y.¥, Chien, C-S.¥, Wang, M-L.¥, Chen, M-T.¥, Yang, Y-P.¥, Yu, Y-L.¥, Chien, Y., Chang, Y-C., Shen, C-C., Chio, C-C., Lu, K-H., Ma, H-I., Chen, K-H., Liu, D-M., Miller, S. A., Chen, Y-W., Huang, P-I., Shin, Y-H., Hung, M-C.* and Chiou, S-H.* Epigenetic regulation of the miR142-3p/Interleukin-6 cirucuit in glioblastoma. Mol Cell 52(5):693-706, 2013. (SCI, IF: 14.018) ¥Co-first authors, *Co-corresponding authors.
Huang, T-H.¥, Huo, L-F.¥, Wang, Y-N., Xia, W., Wei, Y., Chang, S-S., Chang, W-C., Fang, Y-F., Chen, C-T., Lang, J-Y., Tu, C., Wang, Y., Hsu, M-C., Kuo, H-P., Ko, H-W., Shen, J., Lee, H-H., Lee, P-C., Wu, Y., Chen, C-H. and Hung, M-C. Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell 23(6):796-810, 2013. (SCI, IF: 23.523) ¥Co-first authors.
Shen, J., Xia, W., Khotskaya, Y. B., Huo, L., Nakanishi, K., Lim, S-O., Du, Y., Wang, Y., Chang, W-C., Chen, C-H., Hsu, J. L., Wu, Y., Lam, Y. C., James, B. P., Liu, X., Liu, C-G., Patel, D. J. and Hung, M-C. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature 497(7449):383-387, 2013. (SCI, IF: 41.456)
Yu, Y-L.¥,*, Chou, R-H.¥, Shyu, W-C.¥, Hsieh, S-C., Wu, C-S., Chiang, S-Y., Chang, W-J., Chen, J-N., Tseng, Y-J., Lin, Y-H., Lee, W., Yeh, S-P., Hsu, J. L., Yang, C-C., Hung, S-C. and Hung M-C.* Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. EMBO Mol Med 5(4):531-547, 2013. (SCI, IF: 8.665) ¥Co-first authors, *Co-corresponding authors.
Yamaguchi, H., Hsu, J. L., Chen, C-T., Wang, Y-N., Hsu, M-C., Chang, S-S., Du, Y., Ko, H-W., Herbst, R. and Hung M-C. Caspase-independent cell death is involved in the negative effect of EGFR inhibitors on cisplatin in non-small cell lung cancer cells. Clin Cancer Res 19(4):845-854, 2013. (SCI, IF: 8.722) Equal contribution.
Wang, Y., Ding, Q., Yen, C-J., Xia, W., Izzo, J. G., Lang, J-Y., Li, C-W., Hsu, J. L., Miller, S. A., Wang, X., Lee, D-F., Hsu, J-M., Huo, L., LaBaff, A. M., Liu, D., Huang, T-H., Lai, C-C., Tsai, F-J., Chang, W-C., Chen, C-H., Wu, T-T., Buttar, N. S., Wang, K. K., Wu, Y., Wang, H., Ajani, J. and Hung, M-C. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell 21(3):374-387, 2012. (SCI, IF: 23.523)
Li, C-W., Xia, W., Huo, L., Lim, S-O., Wu, Y., Hsu, J. L., Chao, C-H., Yamaguchi, H., Yang, N-K., Ding, Q., Wang, Y., Lai, Y-J., LaBaff, A. M., Wu, T-J., Lin, B-R., Yang, M-H., Hortobagyi, G. N. and Hung, M-C. Epithelial-mesenchyme transition induced by TNF- requires NF-κB mediated transcriptional upregulation of Twist1. Cancer Res 72(5):1290-1300, 2012. (SCI, IF: 9.329)
Liu, M., Lee, D-F., Chen, C-T., Yen, C-J., Li, L-Y.*, Lee, H-J., Chang, C-J., Chang, W-C., Hsu, J-M., Kuo, H-P., Xia, W., Wei, Y., Chiu, P-C., Chou, C-K., Du, Y., Dhar, D., Karin, M., Chen, C-H. and Hung, M-C.* IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell 45(2):171-184, 2012. (SCI, IF: 14.018) Equal contribution, *Corresponding authors.
Ding, Q¥, Chang, C-J.¥, Xie, X., Xia, W., Yang, J-Y., Wang, S-C., Wang, Y., Xia, J., Chen, L., Cai, C., Li, H., Yen, C-J., Kuo, H-P., Lee, D-F., Lang, J., Huo, L., Cheng, X., Chen, Y-J., Li, C-W., Jeng, L-B., Hsu, J. L., Li, L-Y., Tan, A., Curley, S. A., Ellis, L. M., Dubois, R. N. and Hung, M-C. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest 121(11):4526-4536, 2011. (SCI, IF: 13.215) ¥Co-first authors.
Su, J-L.*, Cheng, X., Yamaguchi, H., Chang, Y-W., Hou, C-F., Lee, D-F., Ko, H-W., Hua, K-T., Wang, Y-N., Hsiao, M., Chen, P. B., Hsu, J-M., Bast, R, C, Jr., Hortobagyi, G. N. and Hung, M-C.* FOXO3a dependent mechanism of E1A-Induced chemosensitization. Cancer Res 71(21):6878-6887, 2011. (SCI, IF: 9.329) *Corresponding authors.
Lang, J-Y., Hsu, J. L., Meric-Bernstam, F., Chang, C-J., Wang, Q., Bao, Y., Yamaguchi, H., Xie, X., Woodward, W. A., Yu, D., Hortobagyi, G. N., and Hung, M-C. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell 20(3):341-356, 2011. (SCI, IF: 23.523)
Tsai, K-S., Yang, S-H., Lei, Y-P., Tsai, C-C., Chen, H-W., Hsu, C-Y., Chen, L-L., Wang, H-W., Miller, S. A., Chiou, S-H., Hung, M-C.* and Hung, S-C.* Mesenchymal stem cells promote formation of colorectal tumors in mice. Gastroenterology 141(3):1046-1056, 2011. (SCI, IF: 16.716) *Co-corresponding authors.
Li, L-Y*, Chen, H., Hsieh, Y-H., Wang, Y-N., Chu, H-J., Chen, Y-H., Chen, H-Y., Chien, P-J., Ma, H-T., Tsai, H-C., Lai, C-C., Sher, Y-P., Lien, H-C., Tsai, C-H. and Hung, M-C.* Nuclear ErbB-2 enhances translation and cell growth by activation of rRNA gene transcription. Cancer Res 71(12):4269-4279, 2011. (SCI, IF: 9.329) *Co-corresponding authors.
Chang, C-J., Chao, C-H., Xia, W., Yang, J-Y., Xiong, Y., Li, C-W., Yu, W-H., Rehman, S. K., Hsu, J. L., Lee, H-H., Liu, M., Chen, C-T., Yu, D. and Hung, M-C. p53 regulates epithelial-mesenchymal transition and stem cell properties through regulating miRNAs. Nat Cell Biol 13(3):317-323, 2011. (SCI, IF: 19.679)
Hsu, J-M., Chen, C-T., Chou, C-K., Kuo, H-P., Li, L-Y., Lin, C-Y., Lee, H-J., Wang, Y-N., Liu, M., Liao, H-W., Shi, B., Lai, C-C., Bedford, M. T., Tsai, C-H. and Hung, M-C. Crosstalk between Arg1175 methylation and Tyr1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol 13(2):174-181, 2011. (SCI, IF: 19.679)
Chang, C-J., Yang, J-Y., Xia, W., Chen, C-T, Xie, X., Chao, C-H., Woodward, W. A., Hsu, J. M., Hortobagyi, G. N. and Hung, M-C. EZH2 promotes expansion of breast cancer tumor initiating cells through activation of RAF--catenin signaling. Cancer Cell 19(1):86-100, 2011. (SCI, IF: 23.523)
Wei, Y., Chen, Y-H., Li, L-Y.*, Lang, J., Yeh, S-P., Shi, B., Yang, C-C., Yang, J-Y., Lin, C-Y., Lai, C-C. and Hung, M-C.* CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol 13(1):87-94, 2011. (SCI, IF: 19.679) *Co-corresponding authors.
Cheng, X., Xia, W., Yang, J-Y., Hsu, J. L., Lang, J-Y., Chou, C-K., Sun, H-L., Wyzomierski S. L., Mills, G. B., Muller, W. J., Yu, D. and Hung, M-C. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Res 70(19):7684-7689, 2010. (SCI, IF: 9.329)
Huo, L., Wang, Y-N., Xia, W., Hsu, S-C., Lai, C-C., Li, L-Y., Chang, W-C., Wang, Y., Hsu, M-C, Yu, Y-L., Huang, T-H, Ding, Q., Chen, C-H., Tsai, C-H. and Hung, M-C. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. PNAS 107(37):16125-16130, 2010. (SCI, IF: 9.674)
Yang, J-Y., Chang, C-J., Xia, W., Wang, Y., Wong, K-K., Engelman, J. A., Du, Y., Andreeff, M., Hortobagyi, G. N. and Hung, M-C. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Res 70(11):4709-4718, 2010. (SCI, IF: 9.329)
Su, J-L.*, Chen, P. B., Chen, Y-H., Chen, S-C., Chang, Y-W., Jan, Y-H., Cheng, X., Hsiao, M. and Hung, M-C.* Downregulation of microRNA miR-520h by E1A contributes to anticancer activity. Cancer Res 70(12):5096-5108, 2010. (SCI, IF: 9.329) *Co-corresponding authors.